Environmental pragmatists such as Ben Minteer and Bryan Norton have argued that there is an anti-democratic strain to be found in the work of some nonanthropocentrists. I examine three possible sources of the pragmatists’ concern: the claim that nonanthropocentrists know the political truth, the claim that those who disagree with their basic principle should be excluded from discussions of policy and the claim that their basic principle is self-evident. I argue here that none of these claims are objectionably anti-democratic when (...) understood properly. (shrink)

It may be possible to scientifically test philosophical skepticism; at least this is what I shall maintain. The argument develops the naturalistic insight that there may be no particular reason to suppose that nature has selected Homo sapiens’ epistemic capacities such that we are ideally suited to forming a true theory of everything, or indeed, a true theory of much of anything. Just as chimpanzees are cognitively limited - there are many concepts, ideas, and theories beyond their grasp - so (...) too might our conception of the universe seem limited from the point of view of some creature more “evolved” than humans. On the other hand, some physicists (et al.) have argued that humans are on the verge of discovering a “final theory of everything”. Such epistemic “optimism” seems to directly contradict the idea that we might be cognitively limited. To adjudicate between these views I shall suggest the outlines of several “crucial tests” that involve attempting to create creatures who stand to us, with respect to intelligence and wisdom, as we do to apes. A positive result from any of these experiments will indicate that the skeptical view is correct, while failure to create “higher” intelligences lends support to the epistemic optimists’ position. 2. (shrink)

We discuss a recent attempt by Chris Daly and Simon Langford to do away with mathematical explanations of physical phenomena. Daly and Langford suggest that mathematics merely indexes parts of the physical world, and on this understanding of the role of mathematics in science, there is no need to countenance mathematical explanation of physical facts. We argue that their strategy is at best a sketch and only looks plausible in simple cases. We also draw attention to how frequently Daly and (...) Langford find themselves in conflict with mathematical and scientific practice. (shrink)

This collection explores the impact of Richard Dawkins as scientist, rationalist and one of the most important thinkers alive today. Specially commissioned pieces by leading figures in science, philosophy, literature, and the media, such as Daniel C. Dennett, Matt Ridley, Steven Pinker, Philip Pullman and the Bishop of Oxford, highlight the breadth and range of Dawkins' influence on modern science and culture, from the gene's eye view of evolution to his energetic engagement in public debates on science, rationalism, and religion. (...) The volume includes personal reminiscences and critical debate as well as accessible discussions of science – it provides a stimulating tribute to a remarkable intellectual. (shrink)

Denying the antecedent is an invalid form of reasoning that is typically identified and frowned upon as a formal fallacy. Contrary to arguments that it does not or at least should not occur, denying the antecedent is a legitimate and effective strategy for undermining a position. Since it is not a valid form of argument, it cannot prove that the position is false. But it can provide inductive evidence that this position is probably false. In this role, it is neither (...) defective nor deceptive. Denying the antecedent provides inductive support for rejecting a claim as improbable. (shrink)

We assume that there are certain causes that are morally wrong, worth speaking out against, and working to overcome, e.g., opposition to same sex marriage. This seems to suggest that we should also be boycotting certain businesses; particularly those whose owners advocate such views. Ideally, for the boycotter, this will end up silencing certain views, but this seems to cause two basic problems. First, it appears initially to be coercive, because it threatens the existence of the business. Second, it runs (...) counter to the intuition that we should not force unpopular opinions out of the marketplace of ideas. Boycotting is by its very nature a coercive act, and thus we have to carefully consider what types of actions may warrant this type of coercive action. In this paper, we will argue that an organized boycott is justified if and only if the actions taken by the company have negative consequences that outweigh the negative outcome of the boycott. (shrink)

This paper is a response to Paul Bartha’s ‘Making Do Without Expectations’. We provide an assessment of the strengths and limitations of two notable extensions of standard decision theory: relative expectation theory and Paul Bartha’s relative utility theory. These extensions are designed to provide intuitive answers to some well-known problems in decision theory involving gaps in expectations. We argue that both RET and RUT go some way towards providing solutions to the problems in question but neither extension solves all the (...) relevant problems. (shrink)

Jeremy Davis offered critical comments on our article that argued some boycotts are pro tanto morally wrong. We argued against organized boycotts over expressive acts where the actor is attempting to engage in the market place of ideas. Davis offered two versions of a direct objection to our position – one that boycotts are not attempts to silence and one that boycotts do not cause a chilling effect – and one objection based on reframing the goals of boycotts. In this (...) Response, we argue that Davis’s direct objections are unsound and his reframing objection is consistent with our initial position. (shrink)

We are developing the Neurological Disease Ontology (ND) to provide a framework to enable representation of aspects of neurological diseases that are relevant to their treatment and study. ND is a representational tool that addresses the need for unambiguous annotation, storage, and retrieval of data associated with the treatment and study of neurological diseases. ND is being developed in compliance with the Open Biomedical Ontology Foundry principles and builds upon the paradigm established by the Ontology for General Medical Science (OGMS) (...) for the representation of entities in the domain of disease and medical practice. Initial applications of ND will include the annotation and analysis of large data sets and patient records for Alzheimer’s disease, multiple sclerosis, and stroke. (shrink)

Both formal semantics and cognitive semantics are the source of important insights about language. By developing precise statements of the rules of meaning in fragmentary, abstract languages, formalists have been able to offer perspicuous accounts of how we might come to know such rules and use them to communicate with others. Conversely, by charting the overall landscape of interpretations, cognitivists have documented how closely interpretations draw on the commonsense knowledge that lets us make our way in the world. There is (...) no opposition between these insights. Sooner or later we will have a semantics that responds to both. However, developing such a semantics is profoundly difficult, because there are certain tensions to be overcome in reconciling the two perspectives. For one thing, the overall landscape of meaning does seem to be characterized by a much richer ontology and more dynamic categories than are exhibited by the fragments typically studied in the formal tradition. One sign of strain is the recent tendency to talk of “procedural”, “non-compositional”, or “computational” semantics, as in Hamm, Kamp and van Lambalgen 2006, hereafter HK&vL. We think such locutions can serve as useful reminders to keep semantics fixed on the central question of how language allows us to share information that some have and others need to get. However, there is some danger that formalists will merely by put off by an idea that, taken literally, may not be such a good one. In this short article, we want to explore and defend the traditional realist view attributed by HK&vL to Lewis among others. In fact, this view offers a well-developed, extremely straightforward and robust account of the relation between semantics and cognition. Moreover, while the realist view has ways of accommodating the representationalist insights of DRT (Lewis 1979; Thomason 1990; Stalnaker 1998), it remains unclear how “computational” semantics can account for the key data for the realist view: cases where we judge interlocutors to be ignorant about aspects of meaning in their native language (Kripke 1972; Putnam 1975; Stalnaker 1979; Williamson 1994).. (shrink)

In this paper I attempt to tie together a longstanding dispute between Henry Kyburg and Isaac Levi concerning statistical inferences. The debate, which centers around the example of Petersen the Swede, concerns Kyburg's and Levi's accounts of randomness and choosing reference classes. I argue that both Kyburg and Levi have missed the real significance of their dispute, that Levi's claim that Kyburg violates Confirmational Conditionalization is insufficient, and that Kyburg has failed to show that Levi's criteria for choosing reference class (...) are problematic. Rather, the significance of the Petersen case is to show that other aspects of their respective systems are defective: for Levi his account of credal judgments other than direct inference, and for Kyburg his explanation of how indexes are associated with a body of knowledge. (shrink)

This is just a brief description of the people involved and activities that occurred during a full-day pre-conference event that included a winery tour, a luncheon, apanel discussion of management systems, and a wine tasting. We completed a facility tour at Gallo’s Frei Ranch Winery that highlighted the environmental performance opportunities that exist for wine production. The rest of the day’s schedule was held at MacMurray Ranch. There was a panel that featured presentations and discussions about Gallo of Sonoma’s sustainability (...) management systems, the Benziger Family Winery’s Biodynamic vineyard practices, and the application of environmental management systems in the wine industry and other industries. (shrink)

Thomas Kuhn has argued that scientists never reject a paradigm without simultaneously accepting a new paradigm. Coupled with Kuhn's claim that it is paradigms as a whole, and not individual theories, that are accepted or rejected, this thesis is seen as one of Kuhn's main challenges to the rationality of science. I argue that Kuhn is mistaken in this claim; at least in some instances, science rejects a paradigm despite the absence of a successor. In particular, such a description best (...) fits Kuhn's most discussed example, the Copernican Revolution. By differentiating scientific discoveries into three types, spontaneous, implicit, and directed, we see that Kuhn's thesis holds for spontaneous and implicit discoveries, but not directed discoveries. Directed discoveries must be understood by an alternative account of falsifiability, based on argument by reductio ad absurdum rather than argument by modus tollens as traditional accounts of falsifiability would have it. (shrink)

Contemporary arguments for scientific realism are typically based on some form of inference to the best explanation. Sometimes such arguments concern the methods of science: given the success of scientific methodology, realism offers the best explanation of this success. Sometimes such arguments concern the content of scientific theories: given observed regularities in nature, explanations must be given of those regularities; the best such explanations will be realist. One forceful explanationist argument about the content of science can be based on Hans (...) Reichenbach’s Principle of the Common Cause. Roughly, CC says that whenever an enduring correlation between two events is observed, there must be some preceding event which is the common cause of the two, and is the explanation for the correlation. Rigid adherence to this demand for a common cause, however, supposedly goes beyond the instrumentalist explanatory resources available to the antirealist, and hence CC is taken to be a sufficient condition for realism. Further, one might claim that any argument that realism has greater explanatory power than antirealism depends either explicitly or implicitly on CC, and hence CC is also a necessary condition for realism. (shrink)

Psycholinguistic investigations of the way readers and speakers perceive gender have shown several biases associated with how gender is linguistically realized in language. Although such variations across languages offer interesting grounds for legitimate cross linguistic comparisons, pertinent characteristics of grammatical systems – especially in terms of their gender asymmetries – have to be clearly identified. In this paper, we present a language index for researchers interested in the effect of grammatical gender on the mental representations of women and men. Our (...) index is based on five main language groups (i.e., grammatical gender languages, languages with a combination of grammatical gender and natural gender, natural gender languages, genderless languages with few traces of grammatical gender and genderless languages) and three sets of specific features (morphology, masculine-male generics and asymmetries). Our index goes beyond existing ones in that it provides specific dimensions relevant to those interested in psychological and sociological impacts of language on the way we perceive women and men. We also offer a critical discussion of any endeavor to classify languages according to grammatical gender. (shrink)

_Business Ethics: The Big Picture_ asks students to focus on the assumptions underlying the activity of business. Why does society provide special protections for businesses? What is the purpose of a corporation? What do businesses owe society? And are there some things that shouldn’t be distributed by the free market? These questions are addressed through classic readings from such central figures as Adam Smith and Karl Marx, in addition to contemporary selections from Milton Friedman, R. Edward Freeman, Debra Satz, and (...) others. A number of compelling real-world case studies are also included. (shrink)

Michael A. PetersBeijing Normal UniversityMy deepest condolences to Pepe, Dom and Marcus and to Jim’s grandchildren. Tina and I spent a lot of time at the Marshall family home, often attending dinn...

The stratum-specific treatment effect function is a random variable giving the average treatment effect (ATE) for a randomly drawn stratum of potential confounders a clinician may use to assign treatment. In addition to the ATE, the variance of the stratum-specific treatment effect function is fundamental in determining the heterogeneity of treatment effect values. We offer a non-parametric plug-in estimator, the targeted maximum likelihood estimator (TMLE) and the cross-validated TMLE (CV-TMLE), to simultaneously estimate both the average and variance of the stratum-specific (...) treatment effect function. The CV-TMLE is preferable because it guarantees asymptotic efficiency under two conditions without needing entropy conditions on the initial fits of the outcome model and treatment mechanism, as required by TMLE. Particularly, in circumstances where data adaptive fitting methods are very important to eliminate bias but hold no guarantee of satisfying the entropy condition, we show that the CV-TMLE sampling distributions maintain normality with a lower mean squared error than TMLE. In addition to verifying the theoretical properties of TMLE and CV-TMLE through simulations, we highlight some of the challenges in estimating the variance of the treatment effect, which lack double robustness and might be biased if the true variance is small and sample size insufficient. (shrink)

That there is a heritable or familial component of susceptibility to chronic non‐communicable diseases such as type 2 diabetes, obesity and cardiovascular disease is well established, but there is increasing evidence that some elements of such heritability are transmitted non‐genomically and that the processes whereby environmental influences act during early development to shape disease risk in later life can have effects beyond a single generation. Such heritability may operate through epigenetic mechanisms involving regulation of either imprinted or non‐imprinted genes but (...) also through broader mechanisms related to parental physiology or behaviour. We review evidence and potential mechanisms for non‐genomic transgenerational inheritance of ‘lifestyle’ disease and propose that the ‘developmental origins of disease’ phenomenon is a maladaptive consequence of an ancestral mechanism of developmental plasticity that may have had adaptive value in the evolution of generalist species such as Homo sapiens. BioEssays 29: 145–154, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

We have begun work on two separate but related ontologies for the study of neurological diseases. The first, the Neurological Disease Ontology (ND), is intended to provide a set of controlled, logically connected classes to describe the range of neurological diseases and their associated signs and symptoms, assessments, diagnoses, and interventions that are encountered in the course of clinical practice. ND is built as an extension of the Ontology for General Medical Sciences — a high-level candidate OBO Foundry ontology that (...) provides a set of general classes that can be used to describe general aspects of medical science. ND is being built with classes utilizing both textual and axiomatized definitions that describe and formalize the relations between instances of other classes within the ontology itself as well as to external ontologies such as the Gene Ontology, Cell Ontology, Protein Ontology, and Chemical Entities of Biological Interest. In addition, references to similar or associated terms in external ontologies, vocabularies and terminologies are included when possible. Initial work on ND is focused on the areas of Alzheimer’s and other diseases associated with dementia, multiple sclerosis, and stroke and cerebrovascular disease. Extensions to additional groups of neurological diseases are planned. The second ontology, the Neuro-Psychological Testing Ontology (NPT), is intended to provide a set of classes for the annotation of neuropsychological testing data. The intention of this ontology is to allow for the integration of results from a variety of neuropsychological tests that assay similar measures of cognitive functioning. Neuro-psychological testing is an important component in developing the clinical picture used in the diagnosis of patients with a range of neurological diseases, such as Alzheimer’s disease and multiple sclerosis, and following stroke or traumatic brain injury. NPT is being developed as an extension to the Ontology for Biomedical Investigations. (shrink)

ABSTRACT: This article discusses, principally from an English perspective, globalisation, global citizenship and two forms of education relevant to those developments (global education and citizenship education). We describe what citizenship has meant inside one nation state and ask what citizenship means, and could mean, in a globalising world. By comparing the natures of citizenship education and global education, as experienced principally in England during, approxim-ately, the last three decades, we seek to develop a clearer understanding of what has been done (...) and what might be done in the future in order to develop education for global citizenship. We suggest that up to this point there have been significant differences between the characterisations that have been developed for global education and citizenship education. These differences are revealed through an examination of three areas: focus and origins; the attitude of the government and significant others; and the adoption of pedagogical approaches. We suggest that it would be useful to look beyond old barriers that have separated citizenship education and global education and to form a new global citizenship education. Their separation has in the past only perpetuated the old understandings of citizenship and constructed a constrained view of global education. (shrink)

The decision to initiate invasive, first-in-human trials involving Parkinson’s disease presents a vexing ethical challenge. Such studies present significant surgical risks, and high degrees of uncertainty about intervention risks and biological effects. We argue that maintaining a favorable riskbenefit balance in such circumstances requires a higher than usual degree of confidence that protocols will lead to significant direct and/or social benefits. One critical way of promoting such confidence is through the application of stringent evidentiary standards for preclinical studies. We close (...) with a series of recommendations for strengthening the internal and external validity of preclinical studies, reducing their tendency toward optimism and publication biases, and improving the knowledge base used to design and evaluate preclinical studies. (shrink)